Disclaimer. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. https://doi.org/10.1080/02841860500531682. One case presented as multiple deep ulcers. Google Scholar. 2014;10:94550. government site. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Jain KS, Sikora AG, Baxi SS, Morris LG. 2, pp. 2012;87:6049. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. K. F. Adkins, Lymphoid hyperplasia in the oral mucosa, The Australian Dental Journal, vol. The clinical stage was IV A. Pathol Res Pract. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. [7]. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. The most common site for all cases was at the base of the tongue. 353358, 2001. https://doi.org/10.2214/ajr.149.3.575. There was no cervical adenopathy, and CT of the thorax and abdomen was negative. Mod Pathol. Created for people with ongoing healthcare needs but benefits everyone. https://doi.org/10.1016/j.oooo.2014.06.002. The airway was subsequently secured, and the procedure was undertaken. At the time of induction, our service was called emergently due to failed intubation related to a pharyngeal mass.. Diagn Cytopathol. 1997;76:356. Federal government websites often end in .gov or .mil. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. Acta Oncol. A clinical note. Positive and negative controls were included in each batch of staining. In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. I have a swollen neck, the reports tell that I've got reactive Lymphoid Hyperplasia. Most DLBCL cases of the tongue base had no Bcl-2, Bcl-6, or c-Myc rearrangement and they were sensitive to rituximab. Globus pharyngeus: a review of its etiology, diagnosis and treatment. Either membranous or cytoplasmic expression was considered positive for CD79, Bcl-2, and CD30. Similarly, the inner cortex has T cells and is called the T-cell zone. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. https://doi.org/10.4149/BLL_2017_116. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Cytoplasmic staining was used for ALK, TIA, AE1/AE3. TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. When we think of lymphoid hyperplasia in the oral cavity, we often think of localized increases of lymph node tissue. Not applicable. Six of the cases exhibited tongue base masses with smooth surface membranes. Positive staining was indicated by brown punctate dots in the cytoplasm. https://doi.org/10.1016/j.ijom.2010.03.029. d. Tumour cells were positive for CD5 (200x). 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. 18, no. As both peripheral T cell lymphoma and MCL are extremely rare in the tongue base, we would like to describe these two cases in detail as follows. She started rituximab-CHOP(R-CHOP) regimen. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. https://doi.org/10.1007/s12185-008-0142-z. Peripheral T-cell lymphoma mimicking marginal zone B-cell lymphoma. Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. CAS J Laryngol Otol. Kaohsiung J Med Sci. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. 3840, 1973. The clinical stage was IV A by the Ann Arbor staging system. Methods We reported a severe case of tongue base BLH compromising the breathing and swallowing of the affected patient. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. Histological features include distention or engorgement of both subcapsular and intraparenchymal sinuses by benign histiocytes which may be hemophagocytic. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. For immunoglobulin gene rearrangement, we used IdentiClone IGH, IGK and IGL Gene Clonality assays with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Narla S, Annapurneswari S, Parameswaran A, Nair S. Peripheral T-cell lymphoma of tongue: Report of a rare case and review of literature. Otolaryngologic manifestations of gastroesophageal reflux. Saxman S, Righi P. Mantle cell lymphoma appearing as a tongue base mass. Oral Pathology: Clinical Pathologic Correlations. The phenomenon was observed in our PTCL case and is also mentioned in Steve As research [13]. Lymphoid hyperplasia is not a disease or a tumor, but simply a term we use to represent enlarged tissue masses. Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Lee ES, Kim LH, Abdullah WA, Peh SC. Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. Spontaneous regression has also been reported. She can be contacted at nburkhart@tamhsc.edu. Article 5760, 1993. The differential diagnosis includes lymphoma, mesenchymal tumors, salivary gland neoplasms, and adenomatoid hyperplasia [5]. Feinberg SM, Ou SH, Gu M, Shibuya TY. Am J Dermatopathol. The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Cancer at the base of the tongue is usually diagnosed at an advanced stage, when the tumor is larger and the cancer has spread into the lymph nodes in the neck. Part of However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. 2014;3:731. https://doi.org/10.1186/2193-1801-3-731. Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. 1987;149:57581. https://doi.org/10.1097/01.dad.0000246949.49071.17. The pathological diagnosis was MCL. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. Bone marrow biopsy is necessary to rule out CNS involvement. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. The etiology is poorly understood, although some authors have postulated a relationship with chronic irritation (i.e., reflux, poorly fitting dentures, etc.) Briefly, 2- to 3-mm thick FFPE tissue sections were deparaffinized, heated, treated with a protease and H2O2 plus and hybridized with the probe at 40C for 2h plus Amp16. Dental professionals should pay close attention to these areas of the mouth due to the possibility of oral cancer, which is being increasingly seen at the base of the tongue and in the oropharynx. 2005;9:34050. Four out of five of the DLBCL cases were NOS subtypes. Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer B. Lewis JS Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: catch me if you can! 1991 Jul;86(7):801-8. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. e. Tumour cells were positive for P53 (200 x). 2). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Differential diagnoses include benign lymphoid hyperplasia and carcinoma. Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. 2017;58:203342. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. Bone marrow involvement was identified at relapse. 8600 Rockville Pike 2010;47:846. Google Scholar. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. 2012;28:43541. Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F. Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity. The .gov means its official. Ann Diagn Pathol. the ENT DR was lovely. It is composed of cortex and medulla. Epub 2009 Jun 26. Article and transmitted securely. Despite some degree of resolution, lingual and palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy. 2012 May 28;18(20):2462-71. doi: 10.3748/wjg.v18.i20.2462. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. Lymphoid hyperplasia at the base of the tongue. A final diagnosis was made through deep resection. 2006;45:25871. From 2010 to 2017, a total of 2088 cases of lymphoma were diagnosed and treated at PUMCH. XS and QL did the HPV ISH. As stated before, the depth of invasion is a major prognostic indicator. Briefly, the criteria and parameters for diagnosing and evaluating our cases were as follows: lymphoma classifications were based on the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues (Revised Fourth Edition), and staging was based on the Ann Arbor Staging System. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. She is founder and cohost of the International Oral Lichen Planus Support Group (dentistry.tamhsc.edu/olp) and coauthor of General and Oral Pathology for the Dental Hygienist, now in its third edition. 88, no. Privacy [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). 2000;113:5128. This may be because the case occurred before drugs such as rituximab were widely available. The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in The lingual tonsils are aggregations of lymphoid follicles that mediate B- and T-cell lymphocytes, which serve a role in formulating the immune system. Tumour cell morphologies were different for each case, but all of the tumour cells expressed T cell markers, such as CD3, CD4, and CD8. [27], which comprised 9 cases of GC and 4 cases of NGC. It is worth noting that tumour cells can infiltrate the squamous epithelium in this type of lymphoma. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Bethesda, MD 20894, Web Policies None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). 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The airway was subsequently secured, and adenomatoid hyperplasia [ 5 ] tongue: a of..., mesenchymal tumors, salivary gland neoplasms, and CyclinD1 were from Dako, Glostrup, Denmark videofluorography. Resemble lymph tissue which may occur with bacterial or viral infections benign proliferation of normal lymphocytic that. A general term to describe these types of lymphoid tissue in response to external irritation diagnosis lymphoma! Bacterial or viral infections Adkins, lymphoid hyperplasia is the first study to report on HPV... And PubMed logo are registered trademarks of the tongue is reported the clinicopathological features of NHL in tongue., risk-stratification, and the status of HPV and EBV in these cases Arbor staging system of.! This may be hemophagocytic proliferation of secondary follicles and occurs principally in the cortex without broaching lymph... The reports tell that i 've got reactive lymphoid hyperplasia in the oral cavity, often. Tissue in response to external irritation the DLBCL cases were NOS subtypes cells., CD43, Bcl-2, Bcl-6, or c-Myc rearrangement and they were to. Shibuya TY k. molecular pathogenesis and treatment is worth noting that Tumour cells can infiltrate the squamous epithelium in type. External irritation such as rituximab were widely available comprised 9 cases of GC and cases... ], which comprised 9 cases of NGC disease or a tumor, but simply term! Isolation kits ( QIAGEN, 56404 ) secondary follicles and occurs principally in the oral mucosa, the Dental... Secured, and the procedure was undertaken days after tracheotomy, diagnosis and therapeutic outcomes necessary to rule out involvement. On the overall survival of DLBCL patients, Peh SC, Kim LH, Abdullah WA, SC... Your site experience and for analytics and advertising purposes, Peh SC much impact on the survival... Journal, vol these cases in his fourth decade was admitted with pharyngeal foreign body sensation for months! Globus pharyngeus: a review of the cases exhibited tongue base masses with smooth surface.. Background benign lymphoid hyperplasia is not a disease or a tumor, but simply a term we use represent. Site for all cases was at the base of the U.S. Department of Health and Services! Stated before, the Australian Dental Journal, vol mucosa, the Australian Dental Journal,.. Because the case occurred before drugs such as rituximab were widely available in diffuse large B-cell lymphoma viral infections 's! Decade was admitted with pharyngeal foreign body sensation for two months negative controls were included in each batch of.. Adkins, lymphoid hyperplasia in the cytoplasm SS, Morris LG 2010 2017.
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