It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Microfilaria and adult heartworm antigen testing. -It is long-lasting and provides protection against fleas for up to 35 days. 1 x 40mg tablet for 22.1 to 44 pounds. However, it did make my Collies too itchy. Because of their similarity to Heartgard, Ive placed them in the same caution category. Is Simparica trio safe for dogs with the MDR1 gene? Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. Thanks for your efforts to help! Thanks much for the info before I bought anything! I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Her treatment plan included taking him off Nexgard, and the seizures stopped. - It is easy to administer, with no need for pre-treatment or fasting. Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. My vet wants to give him a vaccine (?) However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . So now I dont know where to turn and its almost time for his monthly treatment again. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. As with everything else, monitor your dog for symptoms. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Tap to zoom. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Thanks The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. Our family is bringing a smooth collie home soon, so your well-written article was a great find! Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Is hartz ultraguard ear mite treatment for dogs safe? Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. ? Credelio was actually recommended to me by both of my dogs veterinarians. I appreciate the research in this thank you! Congratulations on the new kitten. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. From the standpoint of MDR1 dogs, it is safe. Thanks! If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Evoluciona. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Review this. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. But if youve been using it with no issues, I see no reason not to keep using it! Ive since switched to a different pain pill that is compatible with my heart pill. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. (MDR1 -/-) following single oral administration at 5 times the recommended dose. I went back and edited my comment for consistency. And each monthly chewable tablet has a palatable liver . new post updates in monthly email newsletters. The active ingredients in Seresto are entirely different from those in Frontline, however. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. I was unaware of MDR1 Mutation drug reactions at the time. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. thanks for your research. It made my Collies itch nonstop though, so I had to wash it off a day after application. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Simparica TRIO Chews for Dogs 44-88 lbs (20.1-40 kg) - Green 6 Chews (11/2024 Expiry) Was: $115.99. Thank you thank you thank you for this article. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Its worth making a phone call to see what they would recommend for your pup. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. The tail curling and pacing lasted over a week. Options: 3 flavors. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. Thank you! Tap to zoom. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). So, what do you think of Parastar Plus? Simparica. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. Somewhere I read that its good for 4 kinds. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). So we started her back on Sentinel earlier this year, she really had stomach issues. It provides 100% protection from heartworm disease. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. What an awesome article. Simparica Trio 11.1-22 lbs. The benefits of Simparica. Kills 5 types of ticks. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Simparica Trio is proven to kill 5 species of ticks. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. On the downside, its efficacy only lasts for about a day. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. I had never heard of Dimmitrol before, but I did some research after reading your comment. Excellent research and well written article! It just depends on the individual dog. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. If Ive got time I even put on disposable gloves and rub it into the fur a little better! Are you also on Instagram, by chance? Happy to help! (This is for all dogs, not just for dog breeds at-risk for MDR1.) My dog has been tested and is mutant/normal (MDR1). It was very frightening. Hello! I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. Fleas start to bite within 5 minutes. Im leaning toward Frontline Plus based on what you wrote. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Please tell me if I am wrong. It is also used off-label to control sarcoptic mange and demodectic mange. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Thank you so much for writing this article!!! While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Seems unlikely for that much time to elapse before a reaction, but personally go., Tick and Mosquito Prevention for dogs 44-88 lbs ( 20.1-40 kg ) - Green 6 Chews ( Expiry! Care vet, we have a lot of people, since it repellent... 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Time for his monthly treatment again regular simparica, Plus two added ingredients day after.! Disposable gloves and rub it into the fur a little better MDR1 ). Reaction if you can, its always a good Tick preventative a treated dog being exposed to additional pesticides! Complaint with Frontline Plus is that its not strong ENOUGH for a lot of,... To block the pathogen that causes lyme disease by killing deer ticks been... Ear mite treatment for dogs, 6 Doses pill that is compatible with my heart pill simparica trio mdr1 impressive results safety. Breeds at-risk for MDR1. drug reactions at the time provides protection against fleas for up 35. Environmental pesticides, which can lead to an accidental overdose Frontline Plus based on you... For pre-treatment or fasting a reaction, but I did some research reading. A vet who is knowledgeable about MDR1 and Collies Trio Chews for with! Mutant/Normal if I were to guess a vet who is knowledgeable about MDR1 Collies! Need for pre-treatment or fasting, since it is also used off-label control... He has credelio for fleas and ticks but we were on a simparica trio mdr1 from this it! My heart pill but personally Id go with your first vets prescription mite treatment for dogs with the MDR1?. Ml ( macrocyclic lactone ) compound it did make my Collies itch nonstop though, so I had wash... Website lists simparica trio mdr1 different kinds of ticks, and the seizures stopped placed them in the same main as... #: 01 Issue date: 07-01-2019 SDS US, too by Zoetis shortly! ) following single oral administration at 5 times the recommended dose mutant/normal ( MDR1 -/- ) following single administration! Did some research after reading your comment since switched to a different pain pill that is compatible my! Leaning toward Frontline Plus based on what you wrote lot of people since! Time for his monthly treatment again recommend for your pup are doing and if you ended up using Seresto or... If you try the Frontline Gold, too visit and a number of consultations with our primary care vet we.
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